Gregory House, M.D., is a maverick medical genius, who heads a team of young diagnosticians at the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. Most episodes start with a cold open somewhere outside the hospital, showing the events leading to the onset of symptoms for that episode's main patient. The episode follows the team in their attempts to diagnose and treat the patient's illness.

House's nationally-renowned department typically only sees patients who have failed to receive a correct diagnosis at other hospitals, so the cases tend to be exceptionally complex and subtle. Furthermore, House tends to resist accepting cases that he does not find interesting. The medical cases featured are often rare but realistic, and described by Andrew Holtz, the author of The Medical Science of House, M.D., as "a conglomeration of all the worst things that can happen to people from all over the world, crammed into one little community." The team arrives at diagnoses using the Socratic method and differential diagnosis, with House guiding the deliberations.

Episodes